Na+/H+ Exchanger (NHE)

Sodium/hydrogen Exchanger; Sodium-hydrogen Exchanger

Na⁺/H⁺ exchanger (sodium/hydrogen exchanger, NHE) family exchanges Na⁺ for H⁺ according to their concentration gradients, thus promotes the regulation of the stability of cytoplasmic pH and cell volume.

There are nine isoforms of NHE in humans, some NHEs function primarily on the plasma membrane, and others are present on intracellular organelles. NHE1 is expressed in the plasma membrane of virtually all tissues and plays an important role in cardiac health. NHE2 is expressed in the gastrointestinal (GI) tract and contributes to the maintenance of stomach pH and homeostasis, whereas NHE3 predominates in the GI tract and kidneys. NHE4 and NHE5 are abundant in the stomach and brain, respectively. NHE6-9 are expressed in the intracellular compartments of many organ system membranes, but of these NHE8 is the exception and expressed apically.

Na+/H+ Exchanger (NHE) Related Products (52):

By Effects:	Inhibitors (47) Antagonists (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-101840

EIPA	Inhibitor	99.73%
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also enhances autophagy by inhibiting Na⁺/H⁺-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.

HY-N0150

Monensin sodium		≥98.0%
Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na⁺/H⁺ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects.

HY-19693

Cariporide	Inhibitor	99.89%
Cariporide (HOE-642) is a selective Na⁺/H⁺ exchange inhibitor.

HY-101840A

EIPA hydrochloride	Antagonist	98.01%
EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na⁺/H⁺-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.

HY-15991

Tenapanor	Inhibitor	99.65%
Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia.

HY-105064A

Zoniporide mesylate	Inhibitor
Zoniporide mesylate (CP-597396 mesylate) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits ²²Na⁺ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC₅₀=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC₅₀ of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease.

HY-182624

FJ9	Inhibitor
FJ9 is a NHERF1/PDZ inhibitor with human NHERF1 PDZ1 IC₅₀ 1540 μM, NHERF1 PDZ2 IC₅₀ 160 μM, and Frizzled-7-Dishevelled PDZ complex K_i 10 μM. FJ9 binds ligand-binding pockets of NHERF1 PDZ domains to block cognate ligand interactions, disrupts Frizzled-7-Dishevelled interactions, and down-regulates canonical Wnt signaling. FJ9 induces apoptosis in cancer cells with intact β-catenin signaling. FJ9 can be used for the research of non-small cell lung cancer, melanoma.

HY-106150A

Eniporide mesylate	Inhibitor
Eniporide mesylate (EMD 96785 mesylate) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide mesylate specifically inhibits the NHE-1 isoform. Eniporide mesylate improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide mesylate regulates cardiac performance and high-energy phosphate content.

HY-15991A

Tenapanor hydrochloride	Inhibitor	99.55%
Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia.

HY-19273

Rimeporide	Inhibitor	98.63%
Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na⁺/H⁺ exchanger (NHE-1).

HY-18071

BI-9627	Inhibitor	99.71%
BI-9627, a chemical probe, is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC₅₀ = 6 and 31 nM in intracellular pH recovery (pH_i) and human platelet swelling assays). BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 decreases autophagy in HTR-8/SVneo cells. BI-9627 can significantly reduce the pH_i of human sperm and partially reverse the effect of DMA. BI-9627 prolongs Ca²⁺ recovery time in KO hiPSC-CMs. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

HY-138866

Dimethylamiloride	Inhibitor	98.18%
Dimethylamiloride is a specific antiporter inhibitor.

HY-N0150R

Monensin sodium (Standard)
Monensin (sodium) (Standard) is the analytical standard of Monensin (sodium). This product is intended for research and analytical applications. Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects.

HY-105064D

Zoniporide hydrochloride hydrate	Inhibitor	99.16%
Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC₅₀=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM).

HY-106150B

Eniporide hydrochloride	Inhibitor	99.49%
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na⁺/H⁺ exchange inhibitor.

HY-156696

S3226	Inhibitor	99.65%
S3226 is a highly selective NHE-3 inhibitor (IC₅₀<1 μM) that specifically blocks NHE-3-mediated sodium transport. S3226 significantly inhibits blastocyst formation and expansion in mouse embryos, and reduces fluid and electrolyte reabsorption in rat proximal tubules in a dose-dependent manner. S3226 effectively alleviates ischemia-induced acute renal failure by improving renal function parameters, reducing renal tubular injury and restoring intracellular pH homeostasis, without interfering with the normal tubuloglomerular feedback response. S3226 is widely used in studies of acute renal failure and related pathological mechanisms.

HY-139313

NHE3-IN-2	Inhibitor	98.65%
NHE3-IN-2 is a Na⁺/H⁺ exchanger-3 (NHE3) inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin).

HY-174400

SGLT2-IN-2	Inhibitor	99.57%
SGLT2-IN-2 (Compound E9) is an inhibitor of SGLT2. SGLT2-IN-2 significantly enhances the inhibition of SGLT2, NHE1, and SOD enzyme activity. SGLT2-IN-2 has protective effect on the glucose-free DMEM-induced injured cardiomyocytes. SGLT2-IN-2 significantly improves cardiac function in TAC-induced HF mice and inhibits cardiomyocyte hypertrophy as well as collagen deposition. SGLT2-IN-2 can ameliorate myocardial tissue damage and enhance mitochondrial autophagy in injured cardiomyocytes, thereby increasing survival rates in HF mice.

HY-105064

Zoniporide	Inhibitor	99.89%
Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits ²²Na⁺ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC₅₀=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC₅₀ of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease.

HY-18071A

BI-9627 hydrochloride	Inhibitor	98.01%
BI-9627 hydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC₅₀ = 6 and 31 nM in intracellular pH recovery (pH_i) and human platelet swelling assays). BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride decreases autophagy in HTR-8/SVneo cells. BI-9627 hydrochloride can significantly reduce the pH_i of human sperm and partially reverse the effect of DMA. BI-9627 hydrochloride prolongs Ca²⁺ recovery time in KO hiPSC-CMs. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

Name
Email *

	Sorry, but the email address you supplied was invalid.